Which symptom is commonly observed in patients experiencing angioedema?

Angioedema is characterized by localized swelling due to the accumulation of fluid in the deeper layers of the skin and mucous membranes, often as a result of an allergic reaction or the use of certain medications. Difficulty breathing is a common symptom when angioedema affects the airway or throat, leading to swelling that can obstruct airflow. This can be particularly dangerous, as it can result in life-threatening situations requiring immediate medical intervention.

The other symptoms presented, while they may occur in various other conditions, are not specifically indicative of angioedema. Swelling in the extremities can be seen in conditions such as edema or other forms of allergic reactions, but does not directly correlate with the critical nature of angioedema. Severe headache and chronic fatigue are also nonspecific symptoms that may suggest a range of medical issues, but they do not align with the hallmark presentation of angioedema and its potential respiratory complications. Therefore, the symptom of difficulty breathing is most directly associated with the acute risks related to angioedema.